Yo-yo dieting and food insecurity can increase the risk of heart disease

Credit: Unsplash / CC0 Public Domain

Can fluctuations in body weight due to drastic cuts and increased calories lead to physiological changes that increase the risk of heart disease or diabetes later in life?

A new study performed in rats and presented at the American Physiological Society’s annual meeting during the Experimental Biology (EB) 2022 meeting, held in Philadelphia 2-5. April, also provides potential insight into the long-term effects of weight loss diets. as involuntary reductions in food intake caused by food insecurity.

Most previous studies in humans and animals have focused on the short-term effects of weight loss, but researchers say there is less knowledge about how cycles of weight loss and gain can affect long-term health.

For the study, the researchers divided 16 rats into two groups. One group received a normal amount of food throughout the study, while the other group experienced three cycles of a restricted diet (60% of their normal daily food intake) followed by three weeks of normal diet. At the end of the study, researchers used ultrasound to assess the rats’ heart and kidney function and blood tests to assess insulin sensitivity, a measure of how the body processes sugar.

“We found that animals that went through several cycles of weight loss and recovery of body weight had impaired heart and kidney function in the end. They also had more insulin resistance, which can be a cause of diabetes,” said Aline MA de Souza , Ph. D., a postdoc at Georgetown University in Washington, DC, first author of the study. “Although the animals appear to be healthy after ‘recovery’ from the diet, their heart and metabolism are not healthy.”

Also Read:  Type 2 diabetes remission is possible for people with lower BMI

The results also raise questions about public health in the light of the COVID-19 pandemic, such as whether people who had difficulty accessing food due to pandemic shutdowns and economic consequences are facing an increased incidence of cardiovascular problems in the following year.

“Our data support the need for further research into humans to find out if people who do cycles with very restrictive diets to lose weight are at greater risk of developing heart problems later in life,” de Souza said. “We still need to do more research in this area, but the results suggest that the more restrictive the diet, the worse the health outcomes can be. Weight loss diets require careful consideration of long-term health, especially if rapid weight loss is considered. As an option.”

While more research is needed to determine the biological mechanisms behind the results and determine whether the patterns observed in rats are translated into humans, researchers speculate that changes in gene expression in response to calorie restriction may alter biological pathways that regulates blood pressure and insulin metabolism.

Can intermittent fasting diets increase the risk of diabetes? More information: Conference abstract: www.eventscribe.net/2022/EB202 poster? posterTarget = 465472

Provided by Experimental Biology

Quote: Yo-yo dieting and food insecurity can increase the risk of heart disease (2022, April 1) Retrieved April 2, 2022 from https://medicalxpress.com/news/2022-04-yo-yo-dieting-food-insecurity- heart .html

Also Read:  Correction for: Differentiation ability of stromal vascular fraction cells into beige adipocytes is significantly reduced in overweight/obese subjects and insulin resistance: effect of genistein

This document is subject to copyright. Except for any reasonable trade for the purpose of private investigation or research, no part may be reproduced without written permission. The content is provided for informational purposes only.

Leave a Reply

Your email address will not be published.