Type 2 diabetes remission is possible for people with lower BMI

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A new study by Professor Roy Taylor and his team shows that remission from type 2 diabetes is possible for people with lower BMI.

The new study has shown that remission of type 2 diabetes is possible even for some people with lower body weight, delegates heard at the 2022 Diabetes UK Professional Conference today (April 1, 2022).

Results from the Diabetes UK-funded Reversal of Type 2 Diabetes on Normalization of Energy Intake in Non-obese (ReTUNE) trial show that a staggering 70% of participants with lower body weight went into type 2 remission through diet-induced weight loss, despite not living with obesity or overweight.

While obesity increases the risk of developing type 2 diabetes, 10% of people with type 2 diabetes have a BMI that is not in the category of obesity or overweight.

Professor Roy Taylor, lead researcher in the ReTUNE study, Newcastle University, said: “This is very good news for anyone with type 2 diabetes who not only points the way to effective return to health but also challenges the misconceptions that cling to the condition. . “

Full information is available at this website about reversing type 2 diabetes and and ongoing remission including diet plans and information for general practitioners.

People with healthy BMI

Previously, Professor Taylor’s landmark Diabetes Remission Clinical Trial (DiRECT) gave hope to millions of people with type 2 diabetes and obesity or overweight by showing that it was possible for some people to bring their condition into remission through weight loss.

The Counterpoint study, also funded by Diabetes UK, first showed that the secretion of fat from inside the pancreas and liver – the two key organs involved in blood sugar control – was the key to remission from type 2 in people living with obesity or overweight.

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To find out if loss of excess fat from these organs could also help people with BMIs in the healthy area to go into remission from type 2 diabetes, Professor Roy Taylor and his ReTUNE team put 20 people with the condition and a BMI at or just above the healthy range (BMI below 27) on a similar low-calorie diet program as that followed at Counterpoint.

Participants were supported by a medical team to stop all glucose-lowering tablets and follow a strict low-calorie diet (800 kcal per day), consisting of formal meal replacements and non-starchy vegetables for 2-4 weeks, followed by 4-6 weeks. week weight loss maintenance period, which involved the gradual reintroduction of normal foods. All participants had been diagnosed with type 2 diabetes within the last 5 years. This cycle of weight loss and maintenance was repeated up to three times until participants lost between 10 and 15% of their body weight.

After each cycle, the research team measured the amount of fat in the participants’ pancreas and liver and then to see how remission was produced.

Following last year’s promising preliminary results, the study’s complete data confirms for the first time that people with type 2 diabetes and lower BMIs can be supported to bring their type 2 into remission through a structured low-calorie diet program, and that the key to this is to lose harmful fat from the liver and pancreas.

After 12 months, the results showed that:

    Participants’ BMI averaged 22.4 kg / m2 at the end of the study (reduced from an average of 24.8 kg / m2). About three-quarters (70% or 14/20) of participants went into remission from type 2 diabetes during the study, with 50% (10/20) of these going into remission after the first weight loss cycle. An average weight loss of about 8% of body weight was required for remission. In the 14 people who went into remission, the mean HbA1c dropped from 53 mmol / mol at the start of the study to 45 mmol / mol of all diabetes medications, and the blood pressure dropped despite taking less anti-BP medication. Participants’ hepatic and pancreatic fat levels were higher than expected at the start of the trial, but then dropped to normal levels after weight loss.
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Participants reported that they felt satisfied with their weight loss and health improvements and did not report any problems with keeping the weight that they had lost.

Chris Askew, CEO of Diabetes UK, said: “Based on the groundbreaking DiRECT trial, this groundbreaking study by Professor Taylor and his team promotes our understanding of why type 2 diabetes develops and what can be done to treat it. that.

“Our ambition is that as many people as possible should have the chance to bring their type 2 diabetes into remission and live well for a longer period of time. The results of ReTUNE potentially take us a significant step closer to achieving this goal by showing that Remission is not only possible for people with certain body weights.

“It is our hope that ReTUNE – as DiRECT did before – will inform the development of services and support so that many more people with type 2 diabetes will have the option of remission open to them.”

David’s story: Type 2 diabetes and thin

David Childs, ReTune participant from Cleadon in Sunderland, who is now in remission of type 2 diabetes, shares his journey:

“My vision failed, I had constant headaches and I fainted. I knew something was wrong, but I never expected it to be diabetes! I was a healthy 48-year-old with a BMI of 27. My GP ordered blood tests and since they also did not have diabetes in the family, they themselves were surprised that the results said it could be type 2 diabetes – further tests showed that it was true.

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“Immediately, I began my journey to understand more about how to deal with my health, but then I participated in the ReTune trial, and within the first round of the study and the weight loss, I was already in remission of the condition.

“My declining health scared me, that’s what made me act and make choices so I can live a full, healthy life with my family. I exercise and eat right, and I’m determined I will remain in remission. ”

Apparently healthy levels of liver fat can trigger type 2 diabetes, according to a British study by Newcastle University

Citation: Type 2 diabetes remission is possible for people with lower BMIs (2022, April 1) retrieved April 1, 2022 from https://medicalxpress.com/news/2022-04-diabetes-remission-people- bmis.html

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